Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alternative Splicing Regulation of an Alzheimer's Risk Variant in CLU.

International journal of molecular sciences - 25 Sept 2020

Han Seonggyun, Nho Kwangsik, Lee Younghee

Abstract excerpt

Clusterin (CLU) is one of the risk genes most associated with late onset Alzheimer's disease (AD), and several genetic variants in CLU are associated with AD risk. However, the functional role of known AD risk genetic variants in CLU has been little explored. We investigated the effect of an AD risk variant (rs7982) in the 5th exon of CLU on alternative splicing by using an integrative approach of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing
Share to Alzheimer Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Clusterin

Share to Cohort Studies

Share to Genetic Predisposition to Disease

Share to Sex Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 32992916
DOI: 10.3390/ijms21197079
PMCID: PMC7582367

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alternative Splicing Regulation of an Alzheimer's Risk Variant in CLU.PMID 32992916Read ↗

Alzheimer's risk variants in the clusterin gene are associated with alternative splicing.Semantic proximity Read ↗

Integrative analyses of splicing in the aging brain: role in susceptibility to Alzheimer’s DiseaseSemantic proximity Read ↗

A splicing transcriptome-wide association study identifies novel altered splicing for Alzheimer's disease susceptibility.Semantic proximity Read ↗

Brain Region-Dependent Alternative Splicing of Alzheimer Disease (AD)-Risk Genes Is Associated With Neuropathological Features in ADSemantic proximity Read ↗

CLU rs9331888 Polymorphism Contributes to Alzheimer's Disease Susceptibility in Caucasian But Not East Asian Populations.Semantic proximity Read ↗

Exome-wide age-of-onset analysis reveals exonic variants in <i>ERN1, TACR3</i> and <i>SPPL2C</i> associated with Alzheimer’s diseaseSemantic proximity Read ↗

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.Semantic proximity Read ↗

Genetic associations of CLU rs9331888 polymorphism with Alzheimer's disease: A meta-analysis.Semantic proximity Read ↗

Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk.Semantic proximity Read ↗

Effect of CLU genetic variants on cerebrospinal fluid and neuroimaging markers in healthy, mild cognitive impairment and Alzheimer's disease cohorts.Semantic proximity Read ↗

Combined effects of Alzheimer risk variants in the CLU and ApoE genes on ventricular expansion patterns in the elderly.Semantic proximity Read ↗

Genetic association between clusterin polymorphisms and Alzheimer's disease in a Japanese population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.