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Article

ZCCHC17 knockdown phenocopies Alzheimer's disease-related loss of synaptic proteins and hyperexcitability.

Journal of neuropathology and experimental neurology - 20 Jun 2024

Cortese Giuseppe P, Bartosch Anne Marie W, Xiao Harrison, Gribkova Yelizaveta, Lam Tiffany G, Argyrousi Elentina K, Sivakumar Sharanya, Cardona Christopher, Teich Andrew F

Abstract excerpt

ZCCHC17 is a master regulator of synaptic gene expression and has recently been shown to play a role in splicing of neuronal mRNA. We previously showed that ZCCHC17 protein declines in Alzheimer's disease (AD) brain tissue before there is significant gliosis and neuronal loss, that ZCCHC17 loss partially replicates observed splicing abnormalities in AD brain tissue, and that maintenance of ZCCHC17 levels is...

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Identifiers

PMID: 38630575
DOI: 10.1093/jnen/nlae033
PMCID: PMC11187431

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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