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Integrated transcriptomic and proteomic analysis identifies FBXW7 as a key regulator of tau homeostasis in Alzheimer's disease

30 Jul 2025

Abstract excerpt

BackgroundAlzheimer's disease (AD) is a progressive neurodegenerative disorder driven by complex, incompletely understood genetic and pathogenic factors. E3 ubiquitin ligases (E3s), crucial for protein degradation, are implicated in AD, but their specific contributions to its progression remain to be elucidated.ObjectiveThis study aimed to identify dysregulated E3s in AD and elucidate the role of a hub E3, FBXW7,...

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PMID: 40734451
DOI: 10.1177/13872877251361042

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