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Article

ZCCHC17 is a master regulator of synaptic gene expression in Alzheimer’s disease

22 Sept 2017

Abstract excerpt

Motivation: In an effort to better understand the molecular drivers of synaptic and neurophysiologic dysfunction in Alzheimer's disease (AD), we analyzed neuronal gene expression data from human AD brain tissue to identify master regulators of synaptic gene expression. Results: Master regulator analysis identifies ZCCHC17 as normally supporting the expression of a network of synaptic genes, and predicts that...

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PMID: 29028963
DOI: 10.1093/bioinformatics/btx608

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