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Article

Causal interpretations of family GWAS in the presence of heterogeneous effects.

Proceedings of the National Academy of Sciences of the United States of America - 17 Sept 2024

Veller Carl, Przeworski Molly, Coop Graham

Abstract excerpt

Family-based genome-wide association studies (GWASs) are often claimed to provide an unbiased estimate of the average causal effects (or average treatment effects; ATEs) of alleles, on the basis of an analogy between the random transmission of alleles from parents to children and a randomized controlled trial. We show that this claim does not hold in general. Because Mendelian segregation only randomizes alleles...

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Identifiers

PMID: 39269774
DOI: 10.1073/pnas.2401379121
PMCID: PMC11420194

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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