Article
Within family Mendelian randomization studies.
Human molecular genetics - 21 Nov 2019
Davies Neil M, Howe Laurence J, Brumpton Ben, Havdahl Alexandra, Evans David M, Davey Smith George
Abstract excerpt
Mendelian randomization (MR) is increasingly used to make causal inferences in a wide range of fields, from drug development to etiologic studies. Causal inference in MR is possible because of the process of genetic inheritance from parents to offspring. Specifically, at gamete formation and conception, meiosis ensures random allocation to the offspring of one allele from each parent at each locus, and these are...
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