Article

Observational epidemiological studies can mitigate genetic confounding with a genetic relatedness matrix

2025-11-28

Abstract excerpt

Observational studies are commonly used in psychology and epidemiology to identify risk factors correlated with health outcomes. However, these studies are vulnerable to confounding when shared genetic variation influences both the putative risk factor and outcome. Researchers have historically controlled for this type of genetic confounding using polygenic scores, but these scores are often noisy and biased estim...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5ff1c845-32e4-5e89-bbc4-397c87f94ab1
DOI: 10.1101/2025.11.24.690292

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Observational epidemiological studies can mitigate genetic confounding with a genetic relatedness matrixDOI 10.1101/2025.11.24.690292Read

Observational epidemiological studies can mitigate genetic confounding with a genetic relatedness matrix.Semantic proximity Read

Using genetic data to strengthen causal inference in observational research.Semantic proximity Read

Welch-weighted Egger regression reduces false positives due to correlated pleiotropy in Mendelian randomization.Semantic proximity Read

Welch-weighted Egger regression reduces false positives due to correlated pleiotropy in Mendelian randomizationSemantic proximity Read

Identifying cross-disease components of genetic risk across hospital data in the UK Biobank.Semantic proximity Read

Clarifying the causes of consistent and inconsistent findings in genetics.Semantic proximity Read

Causal graphs for the analysis of genetic cohort data.Semantic proximity Read

Multivariate estimation of factor structures of complex traits using SNP-based genomic relationships.Semantic proximity Read

Interpreting population and family-based genome-wide association studies in the presence of confoundingSemantic proximity Read

Simultaneous estimation of bi-directional causal effects and heritable confounding from GWAS summary statisticsSemantic proximity Read

Using the phenotype differences model to identify genetic effects in samples of partially genotyped sibling pairs.Semantic proximity Read

A rigorous method for integrating multiple heterogeneous databases in genetic studiesSemantic proximity Read