Article
Systems Genetics in Human Endothelial Cells Identifies Non-coding Variants Modifying Enhancers, Expression, and Complex Disease Traits.
American journal of human genetics - 4 Jun 2020
Stolze Lindsey K, Conklin Austin C, Whalen Michael B, López Rodríguez Maykel, Õunap Kadri, Selvarajan Ilakya, Toropainen Anu, Örd Tiit, Li Jin, Eshghi Anna, Solomon Alice E, Fang Yun, Kaikkonen Minna U, Romanoski Casey E
Abstract excerpt
The identification of causal variants and mechanisms underlying complex disease traits in humans is important for the progress of human disease genetics; this requires finding strategies to detect functional regulatory variants in disease-relevant cell types. To achieve this, we collected genetic and transcriptomic data from the aortic endothelial cells of up to 157 donors and four epigenomic phenotypes in up to...
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