Article

ROR2 regulates cellular plasticity in pancreatic neoplasia and adenocarcinoma

2023-12-14

Abstract excerpt

Cellular plasticity is a hallmark of pancreatic ductal adenocarcinoma (PDAC) starting from the conversion of normal cells into precancerous lesions to the progression of carcinoma subtypes associated with aggressiveness and therapeutic response. We discovered that normal acinar cell differentiation, maintained by the transcription factor Pdx1, suppresses a broad gastric cell identity that is maintained in metaplas...

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Identifiers and source

Literature Corpus work: 43e43965-c7e8-54e1-8779-c347b0882289
DOI: 10.1101/2023.12.13.571566

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