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Article

Stabilization of the classical phenotype upon integration of pancreatic cancer cells into the duodenal epithelium.

Neoplasia (New York, N.Y.) - 1 Dec 2021

Bozóky Benedek, Fernández Moro Carlos, Strell Carina, Geyer Natalie, Heuchel Rainer L, Löhr J Matthias, Ernberg Ingemar, Szekely Laszlo, Gerling Marco, Bozóky Béla

Abstract excerpt

INTRODUCTION: Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive solid tumors. Based on transcriptomic classifiers, basal-like and classical PDAC subtypes have been defined that differ in prognosis. Cells of both subtypes can coexist in individual tumors; however, the contribution of either clonal heterogeneity or microenvironmental cues to subtype heterogeneity is unclear. Here, we report the...

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Identifiers

PMID: 34798385
DOI: 10.1016/j.neo.2021.11.007
PMCID: PMC8605302

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