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Article

Biological Significance of YAP/TAZ in Pancreatic Ductal Adenocarcinoma

29 Jul 2021

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal types of cancer. Despite major advances in defining the molecular mutations driving PDAC, this disease remains universally lethal with an overall 5-year survival rate of only about 7–8%. Genetic alterations in PDAC are exemplified by four critical genes (KRAS, TP53, CDKN2A, and SMAD4) that are frequently mutated. Among these, KRAS mutation...

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PMID: 34395269
DOI: 10.3389/fonc.2021.700315

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