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Article

YAP1 oncogene is a context-specific driver for pancreatic ductal adenocarcinoma

26 Sept 2019

Abstract excerpt

Transcriptomic profiling classifies pancreatic ductal adenocarcinoma (PDAC) into several molecular subtypes with distinctive histological and clinical characteristics. However, little is known about the molecular mechanisms that define each subtype and their correlation with clinical outcome. Mutant KRAS is the most prominent driver in PDAC, present in over 90% of tumors, but the dependence of tumors on oncogenic...

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Share to Cancer-related gene regulation
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PMID: 31557131
DOI: 10.1172/jci.insight.130811

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