Article

p53 activity licenses transcriptional regulation by YAP/TAZ-TEAD to shape expression landscapes during tumorigenesis

2025-10-01

Abstract excerpt

The tumor suppressor p53 is the most frequently disabled gene in cancer, where its inactivation promotes the transition between transcriptionally distinct pre-malignant and malignant disease. How p53 action shapes these stage-dependent expression landscapes is poorly understood. Using a mouse model where p53 function is restored in advanced pancreatic cancer, we demonstrate that p53 dependent gene expression is de...

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Literature Corpus work: fd5d9718-c2ab-5e25-86f3-1aee4378245a
DOI: 10.1101/2025.09.29.679387

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