Article

Chromatin loop anchors are associated with genome instability in cancer and recombination hotspots in the germline

2017-07-21

Abstract excerpt

<h4>ABSTRACT</h4> Chromatin loops form a basic unit of interphase nuclear organisation, providing contacts between regulatory regions and target promoters, and forming higher level patterns defining self interacting domains. Recent studies have shown that mutations predicted to alter chromatin loops and domains are frequently observed in tumours and can result in the upregulation of oncogenes, but the combination...

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Literature Corpus work: 0f4ba4f1-71b9-5f0f-b04d-a9f37f8cee05
DOI: 10.1101/166934

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