Article
Functional chromatin features are associated with structural mutations in cancer.
BMC genomics - 23 Nov 2014
Grzeda Krzysztof R, Royer-Bertrand Beryl, Inaki Koichiro, Kim Hyunsoo, Hillmer Axel M, Liu Edison T, Chuang Jeffrey H
Abstract excerpt
BACKGROUND: Structural mutations (SMs) play a major role in cancer development. In some cancers, such as breast and ovarian, DNA double-strand breaks (DSBs) occur more frequently in transcribed regions, while in other cancer types such as prostate, there is a consistent depletion of breakpoints in transcribed regions. Despite such regularity, little is understood about the mechanisms driving these effects. A few...
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