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Article

Mechanisms of genomic instability dictate cytosolic DNA composition and dendritic cell mediated anti-tumor immunity

2024-03-13

Abstract excerpt

Patients with microsatellite instable (MSI) colorectal cancers (CRC) face better prognosis than those with the more common chromosomal instable (CIN) subtype due to improved anti-tumor immune responses characterized by high cytotoxic T cell infiltration. Previous investigation identified the cytosolic DNA (cyDNA) sensor STING as necessary for chemokine-mediated T cell recruitment in MSI CRCs. Here, we find cyDNA f...

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Literature Corpus work
0f30b9a2-e861-550e-b75b-7e415bba21b3
DOI
10.1101/2024.03.08.584184
Open publication

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Mechanisms of genomic instability dictate cytosolic DNA composition and dendritic cell mediated anti-tumor immunityDOI 10.1101/2024.03.08.584184
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