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DNA mismatch repair in cancer immunotherapy

8 Jun 2023

Abstract excerpt

Tumors defective in DNA mismatch repair (dMMR) exhibit microsatellite instability (MSI). Currently, patients with dMMR tumors are benefitted from anti-PD-1/PDL1-based immune checkpoint inhibitor (ICI) therapy. Over the past several years, great progress has been made in understanding the mechanisms by which dMMR tumors respond to ICI, including the identification of mutator phenotype-generated neoantigens,...

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PMID: 37325548
DOI: 10.1093/narcan/zcad031

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