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Mutant KRAS Suppresses DNA Sensing by Remodeling Membrane Tension to Clear Extracellular Tumor DNA.

Cancer research - 15 Jul 2026

Cao Di, Zhou Weiyi, Li Zhixiong, Lu Shixun, Hou Zhenlin, Yu Long, Guan Yuanjun, Wang Guoqiang, Liu Yifan, Huang Zhijie, Wang Hao, Dai Jingyi, Li Cong, Wang Jing, Chen Gong

Abstract excerpt

Extracellular tumor-derived DNA (tDNA) has emerged as an important biomarker for cancer diagnosis and monitoring. A better understanding of the mechanisms controlling the abundance of tDNA could help improve biomarker and treatment strategies. In this study, we identified oncogenic KRAS as a critical regulator of tDNA levels. Mutant KRAS promoted tDNA clearance by inducing the tetraspanin CD9, which recruited...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42001481
DOI: 10.1158/0008-5472.CAN-25-4447

Genes

KRAS
CD9
FXR1
ZBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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