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Targeting the loss of cGAS / STING signaling in cancer

20 Jul 2023

Abstract excerpt

The cGAS/STING pathway provides a key host defense mechanism by detecting the accumulation of cytoplasmic double-stranded DNA (dsDNA) and mediating innate and adaptive immune signaling. In addition to detecting pathogen-derived dsDNA, cGAS senses intrinsic dsDNA, such as those associated with defective cell cycle progression and mitophagy that has leaked from the nucleus or mitochondria, and subsequently evokes...

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PMID: 37475576
DOI: 10.1111/cas.15913

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