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DNA Damage and Activation of cGAS/STING Pathway Induce Tumor Microenvironment Remodeling

21 Feb 2022

Abstract excerpt

DNA damage occurs throughout tumorigenesis and development. The immunogenicity of DNA makes it an immune stimulatory molecule that initiates strong inflammatory responses. The cGAS/STING pathway has been investigated as a critical receptor in both exogenous and endogenous DNA sensing to activate the innate immune response. Growing lines of evidence have indicated that activation of the cGAS/STING pathway is...

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PMID: 35265630
DOI: 10.3389/fcell.2021.828657

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