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Article

The Cytosolic DNA-Sensing cGAS–STING Pathway in Cancer

18 Dec 2019

Abstract excerpt

The recognition of DNA as an immune-stimulatory molecule is an evolutionarily conserved mechanism to initiate rapid innate immune responses against microbial pathogens. The cGAS-STING pathway was discovered as an important DNA-sensing machinery in innate immunity and viral defense. Recent advances have now expanded the roles of cGAS-STING to cancer. Highly aggressive, unstable tumors have evolved to co-opt this...

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PMID: 31852718
DOI: 10.1158/2159-8290.cd-19-0761

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