Article

14-3-3 binding maintains the Parkinson’s associated kinase LRRK2 in an inactive state

2024-11-22

Abstract excerpt

Leucine-rich repeat kinase 2 (LRRK2) is a central player in cellular signaling and a significant contributor to Parkinson’s disease (PD) pathogenesis. 14-3-3 proteins are essential regulators of LRRK2, modulating its activity. Here, we present the cryo- electron microscopy structure of the LRRK2:14-3-3 2 autoinhibitory complex, showing that a 14-3-3 dimer stabilizes an autoinhibited LRRK2 monomer by binding to ke...

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Literature Corpus work: ea1bfef0-5f48-51c0-8b40-01dc67b6f582
DOI: 10.1101/2024.11.22.624879

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