Article

Dysregulated Neuroimmune and Anhedonia-like Behavioral Response Following Peripheral Immune Challenge in Mice Carrying the Val66Met Brain Derived Neurotrophic Factor Polymorphism

2025-07-04

Abstract excerpt

Dysregulated inflammatory processes contribute to depression, and gene-environment interactions may influence an individual’s risk and resilience. Reduced brain-derived neurotrophic factor (BDNF) expression increases susceptibility for developing depressive symptoms and the Val66Met (rs6265) single nucleotide polymorphism (SNP) on the BDNF gene is linked to mood disorders. However, whether Val66Met confers increas...

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Literature Corpus work: 0eee6e95-7ea6-5ba6-9b71-550d40847781
DOI: 10.20944/preprints202507.0419.v1

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