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Chronic Inflammation and Neuroprogression in the Pathophysiology in Major Depression.

Advances in experimental medicine and biology - 1 Jan 2026

Bertollo Amanda Gollo, Santos Camila Ferreira, Ignácio Zuleide Maria

Abstract excerpt

Major depressive disorder (MDD) results from interactions between genetic and environmental factors, contributing to neuroinflammation and neurodegeneration. Chronic stress, poor diet, and environmental toxins exacerbate inflammatory responses, leading to neuronal dysfunction and disease progression. Stress-induced activation of the hypothalamic-pituitary-adrenal (HPA) axis promotes a pro-inflammatory state,...

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Identifiers

PMID: 42036577
DOI: 10.1007/978-981-95-6872-7_20

Genes

BDNF
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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