Article
Lipopolysaccharide-induced inflammation leads to acute elevations in pro-inflammatory cytokine expression in a mouse model of Fragile X syndrome.
Physiology & behavior - 1 Mar 2020
Hodges Samantha L, Nolan Suzanne O, Tomac Lindsay A, Muhammad Ilyasah D A, Binder Matthew S, Taube Joseph H, Lugo Joaquin N
Abstract excerpt
Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by a single genetic mutation in the Fmr1 gene, serving as the largest genetic cause of intellectual disability. Trinucleotide expansion mutations in Fmr1 result in silencing and hypermethylation of the gene, preventing synthesis of the RNA binding protein Fragile X mental retardation protein which functions as a translational repressor. Abnormal...
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