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Article

Molecular and functional properties of cortical astrocytes during peripherally induced neuroinflammation.

Cell reports - 10 Aug 2021

Diaz-Castro Blanca, Bernstein Alexander M, Coppola Giovanni, Sofroniew Michael V, Khakh Baljit S

Abstract excerpt

Astrocytic contributions to neuroinflammation are widely implicated in disease, but they remain incompletely explored. We assess medial prefrontal cortex (PFC) and visual cortex (VCX) astrocyte and whole-tissue gene expression changes in mice following peripherally induced neuroinflammation triggered by a systemic bacterial endotoxin, lipopolysaccharide, which produces sickness-related behaviors, including...

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Identifiers

PMID: 34380036
DOI: 10.1016/j.celrep.2021.109508
PMCID: PMC8418871

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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