Article

Three-dimensional regulation of <i>HOXA</i> cluster genes by a <i>cis</i> -element in hematopoietic stem cell and leukemia

2020-04-18

Abstract excerpt

Proper gene regulation is crucial for cellular differentiation, and dysregulation of key genes can lead to diseased states such as cancer. The HOX transcription factors play such a role during hematopoiesis, and aberrant expression of certain HOXA genes is found in certain acute myeloid leukemias (AMLs). While studies have shown that these genes are targeted by a variety of mutant proteins including mutant NPM1,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0ed43350-a0c0-59c9-b2e2-ffec2a690ea4
DOI: 10.1101/2020.04.16.017533

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Three-dimensional regulation of <i>HOXA</i> cluster genes by a <i>cis</i> -element in hematopoietic stem cell and leukemiaDOI 10.1101/2020.04.16.017533Read

<i>PBX3</i> is essential for leukemia stem cell maintenance in <i>MLL</i>‐rearranged leukemiaSemantic proximity Read

<i>Hox</i> gene Dysregulation in Acute Myeloid LeukemiaSemantic proximity Read

Gene regulation in t(6;9) DEK::NUP214 Acute Myeloid Leukemia resembles that of FLT3-ITD/NPM1 Acute Myeloid Leukemia but with an altered HOX/MEIS axisSemantic proximity Read

Epigenetic Perturbations by Arg882-Mutated DNMT3A Potentiate Aberrant Stem Cell Gene-Expression Program and Acute Leukemia Development.Semantic proximity Read

NPM1 mutation mediated HOXBLINC lncRNA activation promotes AML leukemogenesisSemantic proximity Read

Candidate Genes for Expansion and Transformation of Hematopoietic Stem Cells by NUP98-HOX Fusion GenesSemantic proximity Read

Functional Interrogation of <i>HOXA9</i> Regulome in MLLr Leukemia via Reporter-based CRISPR/Cas9 screenSemantic proximity Read

Mutational synergy during leukemia induction remodels chromatin accessibility, histone modifications and three-dimensional DNA topology to alter gene expression.Semantic proximity Read

Aberrant DNA methylation impacts HOX genes expression in bone marrow mesenchymal stromal cells of myelodysplastic syndromes and de novo acute myeloid leukemiaSemantic proximity Read

KAT7 is a therapeutic vulnerability of <i>MLL</i> -rearranged acute myeloid leukemiaSemantic proximity Read

HOXBLINC long non-coding RNA activation promotes leukemogenesis in NPM1-mutant acute myeloid leukemia.Semantic proximity Read

Nuclear Phase Separation Drives NPM1-mutant Acute Myeloid LeukemiaSemantic proximity Read