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Gene regulation in t(6;9) DEK::NUP214 Acute Myeloid Leukemia resembles that of FLT3-ITD/NPM1 Acute Myeloid Leukemia but with an altered HOX/MEIS axis

4 Jan 2024

Abstract excerpt

Acute Myeloid Leukemia (AML) represents a heterogeneous group of hematological malignancies. The t(6;9)(p23;q34) translocation, generating the DEK::NUP214 fusion protein is found in 1% of AML. It causes a highly aggressive disease with poor prognosis in patients with a median age of just 23 [ 1 ]. t(6;9) AML often harbours a FLT3 internal tandem duplication (ITD) mutation as well which contributes to adverse...

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PMID: 38172329
DOI: 10.1038/s41375-023-02118-1

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