Article

KAT7 is a therapeutic vulnerability of <i>MLL</i> -rearranged acute myeloid leukemia

2020-04-25

Abstract excerpt

Histone acetyltransferases (HATs) catalyze the transfer of an acetyl group from acetyl-CoA to lysine residues of histones and play a central role in transcriptional regulation in diverse biological processes. Dysregulation of HAT activity can lead to human diseases including developmental disorders and cancer. Through genome-wide CRISPR-Cas9 screens, we identified several HATs of the MYST family as fitness genes f...

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Literature Corpus work: da6584d5-63ec-56c5-a12c-9afc690e61ff
DOI: 10.1101/2020.04.25.054049

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