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Article

<i>PBX3</i> is essential for leukemia stem cell maintenance in <i>MLL</i>‐rearranged leukemia

15 Apr 2017

Abstract excerpt

Interaction of HOXA9/MEIS1/PBX3 is responsible for hematopoietic system transformation in MLL-rearranged (MLL-r) leukemia. Of these genes, HOXA9 has been shown to be critical for leukemia cell survival, while MEIS1 has been identified as an essential regulator for leukemia stem cell (LSC) maintenance. Although significantly high expression of PBX3 was observed in clinical acute myeloid leukemia (AML) samples, the...

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PMID: 28411381
DOI: 10.1002/ijc.30739

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