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Article

<i>Hox</i> gene Dysregulation in Acute Myeloid Leukemia

1 Feb 2014

Abstract excerpt

In humans, class I homeobox genes (HOX genes) are distributed in four clusters. Upstream regulators include transcriptional activators and members of the CDX family of transcription factors. HOX genes encode proteins and need cofactor interactions, to increase their specificity and selectivity. HOX genes contribute to the organization and regulation of hematopoiesis by controlling the balance between...

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PMID: 24559452
DOI: 10.2217/fon.13.195

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