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Article

Epigenetic Perturbations by Arg882-Mutated DNMT3A Potentiate Aberrant Stem Cell Gene-Expression Program and Acute Leukemia Development.

Cancer cell - 11 Jul 2016

Lu Rui, Wang Ping, Parton Trevor, Zhou Yang, Chrysovergis Kaliopi, Rockowitz Shira, Chen Wei-Yi, Abdel-Wahab Omar, Wade Paul A, Zheng Deyou, Wang Gang Greg

Abstract excerpt

DNA methyltransferase 3A (DNMT3A) is frequently mutated in hematological cancers; however, the underlying oncogenic mechanism remains elusive. Here, we report that the DNMT3A mutational hotspot at Arg882 (DNMT3A(R882H)) cooperates with NRAS mutation to transform hematopoietic stem/progenitor cells and induce acute leukemia development. Mechanistically, DNMT3A(R882H) directly binds to and potentiates...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27344947
DOI: 10.1016/j.ccell.2016.05.008
PMCID: PMC4945461

Genes

NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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