Article
HOXBLINC long non-coding RNA activation promotes leukemogenesis in NPM1-mutant acute myeloid leukemia.
Nature communications - 29 Mar 2021
Zhu Ganqian, Luo Huacheng, Feng Yang, Guryanova Olga A, Xu Jianfeng, Chen Shi, Lai Qian, Sharma Arati, Xu Bing, Zhao Zhigang, Feng Ru, Ni Hongyu, Claxton David, Guo Ying, Mesa Ruben A, Qiu Yi, Yang Feng-Chun, Li Wei, Nimer Stephen D, Huang Suming, Xu Mingjiang
Abstract excerpt
Nucleophosmin (NPM1) is the most commonly mutated gene in acute myeloid leukemia (AML) resulting in aberrant cytoplasmic translocation of the encoded nucleolar protein (NPM1c+). NPM1c+ maintains a unique leukemic gene expression program, characterized by activation of HOXA/B clusters and MEIS1 oncogene to facilitate leukemogenesis. However, the mechanisms by which NPM1c+ controls such gene expression patterns to...
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