Article

NPM1 mutation mediated HOXBLINC lncRNA activation promotes AML leukemogenesis

2020-08-06

Abstract excerpt

<title>Abstract</title> <p><italic>Nucleophosmin </italic>(<italic>NPM1</italic>) is the most commonly mutated gene in acute myeloid leukemia (AML) resulting in aberrant cytoplasmic translocation of the encoded nucleolar protein (NPM1c+). NPM1c+ maintains a unique leukemic gene expression program, characterized by activation of <italic>HOXA</italic>/<italic>B </italic>clusters and <italic>MEIS1 </italic>oncogene...

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Literature Corpus work: 59117b8a-cafb-551e-92bf-81ef3880961b
DOI: 10.21203/rs.3.rs-49109/v1

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