Article

Functional Interrogation of <i>HOXA9</i> Regulome in MLLr Leukemia via Reporter-based CRISPR/Cas9 screen

2020-04-20

Abstract excerpt

<h4>ABSTRACT</h4> Aberrant HOXA9 expression is a hallmark of most aggressive acute leukemias, including human acute myeloid leukemia (AML) and subtypes of acute lymphoblastic leukemia (ALL). HOXA9 overexpression not only predicts poor diagnosis and outcome but also plays a critical role in leukemia transformation and maintenance. However, our current understanding of HOXA9 regulation in leukemia is limited, hi...

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Literature Corpus work: daefd541-bb57-55be-9fb7-2eb43dc038f2
DOI: 10.1101/2020.04.20.050583

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