Article

DEC1 Regulates Human β Cell Functional Maturation and Circadian Rhythm

2025-04-03

Abstract excerpt

<h4>SUMMARY</h4> Stem cell-derived islet (SC-islet) organoids offer hope for cell replacement therapy in diabetes, but their immature function remains a challenge. Mature islet function requires the β-cell circadian clock, yet how the clock regulates maturation is unclear. Here, we show that a circadian transcription factor specific to maturing SC-β cells, DEC1, regulates insulin responsiveness to glucose. SC-isl...

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Literature Corpus work: 6c4fa530-99ea-59c4-9b44-a7e25d30cc5a
DOI: 10.1101/2025.04.03.647023

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