Article

Functional, metabolic and transcriptional maturation of stem cell derived beta cells

2021-04-01

Abstract excerpt

Transplantation of pancreatic islet cells derived from human pluripotent stem cells is a promising treatment for diabetes. Despite progress in stem cell-derived islet (SC-islet) generation, detailed characterization of their functional properties has not been conducted. Here, we generated functionally mature SC-islets using an optimized protocol and comprehensively benchmarked them against primary adult islets. Bi...

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Identifiers and source

Literature Corpus work: 93411916-1028-5061-84e5-53bbcd4d2288
DOI: 10.1101/2021.03.31.437748

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