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Article

Functional plasticity of the human infant β-cell exocytotic phenotype.

Endocrinology - 1 Apr 2013

Fox Jocelyn E Manning, Seeberger Karen, Dai Xiao Qing, Lyon James, Spigelman Aliya F, Kolic Jelena, Hajmrle Catherine, Joseph Jamie W, Kin Tatsuya, Shapiro A M James, Korbutt Gregory, MacDonald Patrick E

Abstract excerpt

Our understanding of adult human β-cells is advancing, but we know little about the function and plasticity of β-cells from infants. We therefore characterized islets and single islet cells from human infants after isolation and culture. Although islet morphology in pancreas biopsies was similar to that in adults, infant islets after isolation and 24-48 hours of culture had less insulin staining, content, and...

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Identifiers

PMID: 23449893
DOI: 10.1210/en.2012-1934

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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