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Integrative proteomics reveals principles of dynamic phosphosignaling networks in human erythropoiesis

1 Dec 2020

Abstract excerpt

Abstract Human erythropoiesis is an exquisitely controlled multistep developmental process, and its dysregulation leads to numerous human diseases. Transcriptome and epigenome studies provided insights into system‐wide regulation, but we currently lack a global mechanistic view on the dynamics of proteome and post‐translational regulation coordinating erythroid maturation. We established a mass spectrometry...

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PMID: 33259127
DOI: 10.15252/msb.20209813

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