Article
Metabolic adaptation pilots the differentiation of human hematopoietic cells
2023-09-17
Abstract excerpt
A continuous supply of energy and metabolic intermediates is an essential prerequisite for survival and the highest priority for the cell. We hypothesize that cell differentiation is a process of optimization of energy flow in a changing environment through phenotypic adaptation. A mechanistic basis of this hypothesis is provided by the established link between core energy metabolism and epigenetic covalent modifi...
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Identifiers and source
- Literature Corpus work
- 185b0d15-e282-5b45-bb92-6b2eb63c4cfb
- DOI
- 10.1101/2023.09.17.558120