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Quantitative proteomics reveals specific metabolic features of acute myeloid leukemia stem cells

19 Jun 2020

Abstract excerpt

Acute myeloid leukemia is characterized by the accumulation of clonal myeloid blast cells unable to differentiate into mature leukocytes. Chemotherapy induces remission in the majority of patients, but relapse rates are high and lead to poor clinical outcomes. Because this is primarily caused by chemotherapy-resistant leukemic stem cells (LSCs), it is essential to eradicate LSCs to improve patient survival. LSCs...

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PMID: 32556243
DOI: 10.1182/blood.2019003654

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