Article

Dissecting autonomous enzymatic variability in single cells

2024-10-04

Abstract excerpt

Metabolic enzymes perform life-sustaining functions in various cellular compartments. Anecdotally, metabolic activity is observed to vary between genetically identical cells, which impacts drug resistance, differentiation, and immune cell activation. However, no large-scale resource systematically reporting metabolic cellular heterogeneity exists. Here, we leverage imaging-based single-cell spatial proteomics to r...

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Literature Corpus work: 779691e1-1f1e-5171-b044-66663a66d0c1
DOI: 10.1101/2024.10.03.616530

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