Genome dilution by cell growth drives starvation-like proteome remodeling in mammalian and yeast cells

Abstract excerpt

<h4>SUMMARY</h4> Cell size is tightly controlled in healthy tissues and single-celled organisms, but it remains unclear how size influences cell physiology. Increasing cell size was recently shown to remodel the proteomes of cultured human cells, demonstrating that large and small cells of the same type can be biochemically different. Here, we corroborate these results in mouse hepatocytes and extend our analysis...

Topics

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• Cell Division
• Cell Enlargement
• Cell Proliferation
• Cell Size
• Cellular Senescence
• Mutation
• Phenotype
• Proteome

Identifiers and source

Literature Corpus work

50809bc9-9841-5784-8d0a-9d8326f0942f

DOI

10.1101/2023.10.16.562558