Single cell spatial proteomics maps human liver zonation patterns and their vulnerability to fibrosis

Abstract excerpt

Understanding protein distribution patterns across tissue architecture is crucial for deciphering organ function in health and disease. Here, we applied single-cell Deep Visual Proteomics to perform spatially-resolved proteome analysis of individual cells in native tissue. We combined this with a novel strategic cell selection pipeline and a continuous protein gradient mapping framework to investigate larger clini...

Topics

Open a Topic to create a Post that cites this publication.

• alpha 1-Antitrypsin
• alpha 1-Antitrypsin Deficiency
• Hepatocytes
• Liver Cirrhosis
• Machine Learning
• Proteome
• Single-Cell Analysis
• Unfolded Protein Response

Identifiers and source

Literature Corpus work

d3278e11-9237-5b0c-b486-3171a0cebbb0

DOI

10.1101/2025.04.13.648568