Article

High-Sensitivity Top-Down Proteomics Reveals Enhanced Maturation of Micropatterned Induced Pluripotent Stem Cell-Derived Cardiomyocytes

2025-05-15

Abstract excerpt

<h4>ABSTRACT</h4> Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are increasingly used for disease modeling, drug discovery, and precision medicine, yet their utility is often limited by their immature phenotype. One promising maturation strategy involves using micropatterned substrates that mimic native cardiomyocytes’ organizational growth and stiffness. However, the molecular maturity o...

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Literature Corpus work: f28a1769-4ac3-5ab4-a788-10cd161fe77a
DOI: 10.1101/2025.05.12.653499

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