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Article

A general approach for selection of epitope-directed binders to proteins

29 Apr 2024

Abstract excerpt

Directing antibodies to a particular epitope among many possible on a target protein is a significant challenge. Here, we present a simple and general method for epitope-directed selection (EDS) using a differential phage selection strategy. This involves engineering the protein of interest (POI) with the epitope of interest (EOI) mutated using a systematic bioinformatics algorithm to guide the local design of an...

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PMID: 38683990
DOI: 10.1073/pnas.2317307121

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