Article

A general approach for selection of epitope-directed binders to proteins

2022-10-25

Abstract excerpt

Directing antibodies to a particular epitope among many possible on a target protein is a significant challenge. Here we present a simple and general method for epitope-directed selection (EDS) using a differential phage selection strategy. This involves engineering the protein of interest (POI) with the epitope of interest (EOI) mutated using a systematic bioinformatics algorithm to guide the local design of an E...

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Literature Corpus work: f51d987a-fca7-5aa9-8dd8-16ff2a23fbf1
DOI: 10.1101/2022.10.24.513434

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