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Generation and validation of recombinant antibodies to study human aminoacyl-tRNA synthetases

14 Aug 2020

Abstract excerpt

Aminoacyl-tRNA synthetases (aaRSs) have long been viewed as mere housekeeping proteins and have therefore often been overlooked in drug discovery. However, recent findings have revealed that many aaRSs have noncanonical functions, and several of the aaRSs have been linked to autoimmune diseases, cancer, and neurological disorders. Deciphering these roles has been challenging because of a lack of tools to enable...

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PMID: 32817337
DOI: 10.1074/jbc.ra120.012893

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