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Article

ESCAPE: assigning site-specific activity to covalent ligands in cells by prime editing

2026-07-29

Abstract excerpt

Chemical proteomics has identified covalent ligands targeting cysteine residues across many hundreds of human proteins. The functional effects of these liganding events, however, remain challenging to assign at scale. Here we describe ESCAPE (Endogenous Site-specific Competition Assays using Prime Editors), a platform for the site-resolved functional analysis of covalent ligands in cells. In this method, cysteine-...

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Literature Corpus work
ee0fc3d1-77ab-5ae1-b4ab-04d0d595ed23
DOI
10.64898/2026.07.28.741261
Open publication

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ESCAPE: assigning site-specific activity to covalent ligands in cells by prime editingDOI 10.64898/2026.07.28.741261
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