Article

Oxytocin alleviated colitis and colitis-associated colorectal tumorigenesis by targeting fucosylated MUC2

2023-08-17

Abstract excerpt

Colon cancer is commonly regarded as hormone-independent. However, there have been reports suggesting the involvement of sex hormones in colon cancer development. Nevertheless, the role of hormones from the hypothalamus-hypophysis axis in colitis-associated colorectal cancer (CAC) remains uncertain. In this study, we observed a significant reduction in the expression of the oxytocin receptor (OXTR) in colon sample...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0e6f000d-5a08-5de4-a6c8-50f1d4ed4210
DOI: 10.1101/2023.08.17.553684

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Oxytocin alleviated colitis and colitis-associated colorectal tumorigenesis by targeting fucosylated MUC2DOI 10.1101/2023.08.17.553684Read

The ulcerative colitis associated gene FUT8 regulates the quantity and quality of secreted mucinsSemantic proximity Read

Morphological and Functional Colonic Defects Caused by a Mutated Thyroid Hormone Receptor α.Semantic proximity Read

Guanylyl cyclase C signaling axis and colon cancer prevention.Semantic proximity Read

Fmo5 plays a sex-specific role in goblet cell maturation and mucus barrier formationSemantic proximity Read

Fundamental transport mechanism of mucin-2 ER-to-Golgi trafficking identifies source of ER stress in inflammatory bowel diseaseSemantic proximity Read

Acyloxyacyl Hydrolase Modulates the Gut Microbiome Through Transcriptional Regulators of Corticotropin-Releasing FactorSemantic proximity Read

High-fat diet impacts the colon and its transcriptome in a sex-dependent manner that is modifiable by estrogensSemantic proximity Read

Lectin–epithelial interactions in the human colonSemantic proximity Read

GPR4 knockout attenuates intestinal inflammation and forestalls the development of colitis-associated colorectal cancer in murine modelsSemantic proximity Read

Mice overexpressing β-1,4-Galactosyltransferase I are resistant to TNF-induced inflammation and DSS-induced colitis.Semantic proximity Read

Altered expression of Butyrophilin ( <i>BTN</i> ) and BTN‐like ( <i>BTNL</i> ) genes in intestinal inflammation and colon cancerSemantic proximity Read

Sex differences in colonic inflammation are driven by epithelial-specific expression of estrogen receptor alphaSemantic proximity Read